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Expert Rev Cardiovasc Ther ; 20(2): 87-90, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-35180029

RESUMO

Rare cases of myocarditis and pericarditis after COVID-19 mRNA vaccination have been recently reported in male adolescents and young adults. Acute myocarditis and pericarditis following COVID-19 mRNA vaccination in male adolescents and young adults may be connected with age-related lower levels of T-bet and PD-1 in predisposed individulas with T-bet polymorphisms by the release od autoreactive CD8+CTL. Upregulatiomn of T-Bet and PD-1 by estrogen might explai the higher incidence of men developing myocarditis or pericarditis in comparison to women.


Assuntos
COVID-19 , Miocardite , Pericardite , Adolescente , COVID-19/prevenção & controle , Vacinas contra COVID-19/efeitos adversos , Feminino , Humanos , Masculino , Miocardite/complicações , Pericardite/epidemiologia , Pericardite/etiologia , RNA Mensageiro , Vacinação/efeitos adversos , Adulto Jovem
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